• Aleksandra Araszkiewicz, Dariusz Naskret, Pawel Niedzwiecki, Pawel Samborski, Bogna Wierusz-Wysocka, and Dorota Zozulinska-Ziolkiewicz.
• Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, Poznan, Poland. olaaraszkiewicz@interia.pl
• Diabetes Technol. Ther. 2011 Aug 1; 13 (8): 837-42.

BackgroundSkin autofluorescence (AF) measured with an AF reader device is a noninvasive tool to measure the tissue accumulation of advanced glycation end products (AGEs). The aim of the study was to assess the association between AF and microvascular complications in type 1 diabetes mellitus (DM1).MethodsThe study population consisted of 140 DM1 patients, 28 years old (interquartile range [IQR], 23-35), 76 of whom were women, with disease duration of 13 years (IQR, 8-19). We used the AGE Reader (DiagnOptics, Groningen, The Netherlands) to measure the AF phenomenon, which occurs because of fluorescent properties of AGEs. The patients were divided according to the presence or absence of diabetes-associated microvascular complications: retinopathy, nephropathy, and neuropathy and any microangiopathy.ResultsThe median AF was 2.0 (IQR, 1.7-2.4). In the univariate logistic regression AF was significantly associated with retinopathy (odds ratio [OR] 2.47, 95% confidence interval [CI] 1.26-4.84, P = 0.008), nephropathy (OR 3.15, 95% CI 1.34-7.39, P = 0.008), neuropathy (OR 3.17, 95% CI 1.46-6.90, P = 0.003), and any microvascular complication (OR 2.94, 95% CI 1.46-5.92, P = 0.002). Multivariate logistic regression showed that skin AF was independently associated only with diabetic neuropathy (OR 2.98, 95% CI 0.99-8.90, P = 0.05).ConclusionsThe tissue accumulation of AGE is significantly associated with microvascular complications in DM1.

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