• Cell and tissue research · Mar 2018

    Review

    Neutrophils in critical illness.

    • Braedon McDonald.
    • Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, HRIC 4C51, 3230 Hospital Dr. NW, Calgary, AB, T2N 4N1, Canada. braedon.mcdonald@icloud.com.
    • Cell Tissue Res. 2018 Mar 1; 371 (3): 607-615.

    AbstractDuring critical illness, dramatic alterations in neutrophil biology are observed including abnormalities of granulopoeisis and lifespan, cell trafficking and antimicrobial effector functions. As a result, neutrophils transition from powerful antimicrobial protectors into dangerous mediators of tissue injury and organ dysfunction. In this article, the role of neutrophils in the pathogenesis of critical illness (sepsis, trauma, burns and others) will be explored, including pathological changes to neutrophil function during critical illness and the utility of monitoring aspects of the neutrophil phenotype as biomarkers for diagnosis and prognostication. Lastly, we review findings from clinical trials of therapies that target the harmful effects of neutrophils, providing a bench-to-bedside perspective on neutrophils in critical illness.

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