• American heart journal · Jul 2012

    Multicenter Study

    The impact of peripheral arterial disease on early outcome after transcatheter aortic valve implantation: results from the German Transcatheter Aortic Valve Interventions Registry.

    • Jan-Malte Sinning, Martin Horack, Eberhard Grube, Ulrich Gerckens, Raimund Erbel, Holger Eggebrecht, Ralf Zahn, Axel Linke, Horst Sievert, Hans-Reiner Figulla, Karl-Heinz Kuck, Karl Eugen Hauptmann, Ellen Hoffmann, Rainer Hambrecht, Gert Richardt, Stefan Sack, Jochen Senges, Georg Nickenig, and Nikos Werner.
    • Medizinische Klinik und Poliklinik II, Universitätsklinikum, Bonn, Germany.
    • Am. Heart J. 2012 Jul 1; 164 (1): 102-10.e1.

    BackgroundA significant proportion of patients undergoing transcatheter aortic valve implantation (TAVI) have concomitant peripheral arterial disease (PAD), which plays a crucial role in the preinterventional selection process of determining an optimal vascular access site. The aim of our study was to determine the impact of PAD on clinical outcome after TAVI in a real-world setting.MethodsA total of 1,315 patients (mean logistic European System for Cardiac Operative Risk Evaluation 20.6% ± 13.7%) underwent TAVI in 27 centers and were included in the prospective German TAVI Registry.ResultsOf the 1,315 patients with TAVI, 330 (25.1%) had PAD. These patients had a higher logistic European System for Cardiac Operative Risk Evaluation score (27.7% ± 16.0% vs 18.3% ± 12.0%, P < .0001), mainly attributed to more frequent and severe comorbidities. Compared with patients without PAD, patients with PAD had a higher rate of vascular complications (28.5% vs 20.7%, P < .01), dialysis-dependent renal failure (11.2% vs 5.4%, P < .001), myocardial infarction (1.2% vs 0.3%, P < .05), and, subsequently, 30-day mortality (12.7% vs 6.9%, P < .001). Choosing a surgical approach, for example, transapical access, did not reduce the periprocedural risk associated with PAD; in-hospital mortality was 15.7% for surgical and 10.5% for percutaneous patients with TAVI having PAD (P < .001). In a multivariate regression analysis, PAD was an independent predictor of 30-day mortality (hazard ratio 1.8, 95% CI 1.2-2.7, P = .004) after TAVI.ConclusionsIn this real-world TAVI Registry, PAD was an independent predictor of mortality in patients with percutaneous and surgical TAVI, including vascular complications. Assessment of PAD should play a crucial role in the preinterventional selection process, regardless of the access strategy.Copyright © 2012 Mosby, Inc. All rights reserved.

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