• Nuklearmed Nucl Med · Feb 1988

    Comparative Study

    Localization of 99mTc-diphosphonates in newly formed bone matrix as a measure of bone lesion detectability.

    • C Schuemichen, T Krause, G Umbach, and T Wolff.
    • Department of Nuclear Medicine, Albert-Ludwigs-University, Freiburg i. Br., FRG.
    • Nuklearmed Nucl Med. 1988 Feb 1; 27 (1): 8-11.

    AbstractThe lesion-to-normal-bone ratios of DBA-MDP (dibutylamino-methylene-diphosphonate), DPD (dicarboxypropane-diphosphonate) and MDP (methylene-diphosphonate) each labeled with 99mTc, were evaluated in experimental bone lesions. In 3-day old lesions this ratio was increased twofold for DBA-MDP in comparison with MDP and DPD which showed nearly equal ratios. Later on these differences became negligibly small. It is concluded that 99mTc-DBA-MDP is fixed more strongly in the immature bone matrix and that this will lead to an improvement in the detectability of lesions containing larger amounts of immature bone matrix.

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