• Laurence Valeyrie-Allanore, Sylvie Bastuji-Garin, Sarah Guégan, Nicolas Ortonne, Martine Bagot, Jean-Claude Roujeau, Jean E Revuz, Janine Wechsler, and Pierre Wolkenstein.
• Department of Dermatology, Assistance Publique - Hôpitaux de Paris, Hôpital Henri-Mondor, Université Paris Est, LIC EA4393, F-94010, Créteil, France. laurence.allanore@hmn.aphp.fr
• J. Am. Acad. Dermatol. 2013 Feb 1; 68 (2): e29-35.

BackgroundThe prognosis of toxic epidermal necrolysis (TEN), Stevens-Johnson syndrome (SJS), and SJS/TEN overlap syndrome has been assessed using a disease-specific severity score (SCORTEN) based on clinical and laboratory data. Histologic data may improve outcome prediction.ObjectiveWe sought to evaluate whether dermal mononuclear infiltration and epidermal necrosis predict survival of patients with TEN, SJS, or SJS/TEN.MethodsWe conducted a retrospective review of clinical records and skin biopsy specimens read without knowledge of clinical data.ResultsWe identified 108 patients (SJS, n = 42; SJS/TEN, n = 36; TEN, n = 30). Overall mortality was 21.3%. Dermal infiltration and epidermal necrosis were not associated with time from disease onset to biopsy. Extensive dermal infiltrates were seen in 19 (18.5%) patients and full-thickness epidermal necrosis in 56 (52%) patients. Dermal infiltrate severity was not associated with day-1 (D1) SCORTEN or hospital death. Epidermal necrosis severity showed trends toward associations with D1 SCORTEN (P = .11) and hospital death (P = .06). In univariate analyses, full-thickness epidermal necrosis was significantly associated with hospital death (32.1% vs 11.4%, P = .017) and worse D1 SCORTEN values (1.98 ± 1.29 vs 1.55 ± 1.21; P = .04). In the bivariate analysis, however, D1 SCORTEN remained significantly associated with hospital death (odds ratio = 3.07, 95% confidence interval 1.83-5.16) but the association with full-thickness epidermal necrosis was no longer significant (odds ratio = 2.02, 95% confidence interval 0.65-7.12).LimitationsRetrospective study design and indirect assessment of progression are limitations.ConclusionFull-thickness epidermal necrosis was associated with mortality but did not independently predict hospital death after adjustment based on the SCORTEN value. Dermal infiltrate severity was not associated with hospital death.Copyright © 2011 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.

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