• Hilal Kutluhan, Yucel Yuce, Fatih Dogu Geyık, Kemal Tolga Saracoglu, and Banu Cevik.
• Anaesthesiology and Reanimation Department, University of Health Sciences Kartal Dr. Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey.
• Int. J. Clin. Pract. 2021 Oct 1; 75 (10): e14602.

ObjectiveWe compared inhalational and total intravenous anaesthesia about haemodynamic stability and oxidative stress response in vertebral surgery.Backgrounds And MethodsFifty-nine elective vertebral surgery patients were randomly divided into propofol (Group P) and desflurane (Group D) groups. Intraoperative haemodynamic parameters, preoperative and post-operative native thiol, total thiol, disulfide, C-reactive protein (CRP), albumin, cortisol and catalase levels were studied.ResultsPost-operative native thiol and total thiol values in Group P were higher (P = .044 and P = .031). Post-operative albumin value in Group P was lower than the preoperative value (P < .001). The post-operative CRP and albumin values in Group D were lower than the preoperative value. The cortisol value was high (P = .03, P < .001 and P < .001). The post-operative albumin value in Group P was higher (P = .03). There is a positive correlation between CRP and disulfide values (P = .017), between albumin and native thiol values (P < .001), between total thiol value (P < .001), between the cortisol value and the disulfide/native thiol value (P = .002) and between native/total thiol value (P = .003) and a negative correlation between disulfide/native thiol value (P = .005), between disulfide/total thiol value (P = .003) and between the native/total thiol value (P = .001).ConclusionDynamic thiol/disulfide haemostasis reflects oxidative stress. Propofol positively contributes to oxidative stress in elective vertebral surgery.© 2021 John Wiley & Sons Ltd.

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