• P Wang, S L Lin, L H Zhang, Z Li, Q Liu, J X Gao, D M Liu, J J Bo, and Y R Huang.
• Department of Urology, Renji Hospital, Shanghai Jiao Tong University, Shanghai, China.
• Eur J Surg Oncol. 2014 Mar 1; 40 (3): 255-9.

ObjectivesThis research aims to specify the prognostic value of P-cadherin on recurrence and progression in non-muscle-invasive bladder cancers (NMIBC).MethodsA total of 110 NMIBC cases were collected and P-cadherin protein was assessed by immunohistochemical test in these samples. Correlations between P-cadherin expression and clinicopathologic features were analyzed. For recurrence-free and progression-free survival, Kaplan-Meier log-rank test was used. Then Cox univariate and multivariate analyses were further performed.ResultsP-cadherin high expression correlated with tumor progression (P = 0.031). Kaplan-Meier results showed that patients with high P-cadherin expression had worse progression-free survival (P = 0.034) but not recurrence-free survival (P = 0.133) than low-expression patients. Cox regression results showed P-cadherin expression was an independent predictor for progression (P = 0.042) but not recurrence (P = 0.139) in NMIBC.ConclusionsOur results demonstrated that P-cadherin expression correlated with tumor progression and could be taken as an independent predictor for progression in NMIBC.Copyright © 2014 Elsevier Ltd. All rights reserved.

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