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- E-S Strobel and E Fritschka.
- Paracelsus-Klinik, Bad Elster, Germany.
- Onkologie. 2002 Feb 1; 25 (1): 24-7.
AbstractLess than 1% of breast cancers occur between the age of 20 and 30 years, but more than 50% of breast cancers under the age of 30 years are hereditary. Breast cancer mainly occurs sporadically, however, in 5 to maximally 10% of cases a genetic predisposition is present. Mutations in the already sequenced tumor suppressor genes BRCA1 and BRCA2 account for 60-70% of these hereditary breast cancers. The chromosomal location of BRCA1 is 17q21 and that of BRCA2 is 13q12-13. Screening procedures and possible prevention strategies for women with mutations in the BRCA1 and BRCA2 genes are discussed. They include the use of tamoxifen.Copyright 2002 S. Karger GmbH, Freiburg
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