• Zhonghua Liu Xing Bing Xue Za Zhi · Jan 2009

    Meta Analysis

    [Meta-analysis on the relationship between colorectal cancer and Helicobacter pylori infection].

    • Yan Zhang, Chang Gao, and Jing-Hua Zhai.
    • School of Public Health, Jining Medical University, Jining 272013, China.
    • Zhonghua Liu Xing Bing Xue Za Zhi. 2009 Jan 1; 30 (1): 73-7.

    ObjectiveAnalyzing all the related studies that have been published in the world to evaluate the relationship between colorectal cancer (including colorectal adenomas) and Helicobacter pylori infection by means of Meta-analysis.MethodsTo analyze the 14 references consistent with inclusion criteria by reviewing manager 4.2, calculating the odds ratio and 95% confidence interval, then drawing funnel plot. Results The total sample size is 3165, cases and controls are 1330 and 1835, respectively. The pooled OR is 1.36, and 95% confidence interval 1.01, 1.82. The graphical funnel plot appearing asymmetrical, but analyzing by sensitivity analysis and fail-safe number calculation. The results are affected by publication bias.ConclusionThe results of our Meta-analysis show that Helicobacter pylori infection is a possible risk of colorectal cancer.

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