• Hawkins C Gay, Arjun Sinha, Eriberto Michel, Anthony B Mozer, Ashley Budd, Matthew J Feinstein, Keith H Benzuly, Abbas Al-Qamari, Amit A Pawale, and Esther E Vorovich.
• Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
• ESC Heart Fail. 2020 Oct 15.

AbstractCoronavirus disease 2019 (COVID-19) is a global pandemic increasingly encountered in the clinical setting. It typically manifests as a respiratory illness, although cardiac involvement is common and portends a worse prognosis. We present the case of a 56-year-old male admitted with COVID-19 fulminant myocarditis and cardiogenic shock. We discuss important aspects of the multidisciplinary and interventional care involved in treating cardiogenic shock as well as the likely mechanisms of, and potential treatment for, COVID-19 myocarditis. The various pathways of myocardial injury, including direct viral damage, macrophage activation, and lymphocytic infiltration, are outlined in detail in addition to associated pathology such as cytokine release syndrome. COVID-19 is a complex and multisystem disease process; in addition to supportive care, specific consideration should be given to the underlying mechanism of injury for each patient.© 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology.

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