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Diagnostics (Basel) · Mar 2020
Platelet Mitochondrial Respiration, Endogenous Coenzyme Q10 and Oxidative Stress in Patients with Chronic Kidney Disease.
- Anna Gvozdjáková, Zuzana Sumbalová, Jarmila Kucharská, Mária Komlósi, Zuzana Rausová, Oľga Vančová, Monika Számošová, and Viliam Mojto.
- Pharmacobiochemical Laboratory of 3rd Department of Internal Medicine, Faculty of Medicine, Comenius University in Bratislava, Sasinkova 4, 811 08 Bratislava, Slovakia.
- Diagnostics (Basel). 2020 Mar 23; 10 (3).
AbstractChronic kidney disease (CKD) is characterized by a progressive loss of renal function and a decrease of glomerular filtration rate. Reduced mitochondrial function, coenzyme Q10 (CoQ10), and increased oxidative stress in patients with CKD contribute to the disease progression. We tested whether CoQ10 levels, oxidative stress and platelet mitochondrial bioenergetic function differ between groups of CKD patients.
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