• Int J Mol Sci · Oct 2014

    Review

    Novel formulations for antimicrobial peptides.

    • Ana Maria Carmona-Ribeiro and Letícia Dias de Melo Carrasco.
    • Biocolloids Laboratory, Instituto de Química, Universidade de São Paulo, Av. Lineu Prestes 748, 05508-000 São Paulo, SP, Brazil. amcr@usp.br.
    • Int J Mol Sci. 2014 Oct 9; 15 (10): 18040-83.

    AbstractPeptides in general hold much promise as a major ingredient in novel supramolecular assemblies. They may become essential in vaccine design, antimicrobial chemotherapy, cancer immunotherapy, food preservation, organs transplants, design of novel materials for dentistry, formulations against diabetes and other important strategical applications. This review discusses how novel formulations may improve the therapeutic index of antimicrobial peptides by protecting their activity and improving their bioavailability. The diversity of novel formulations using lipids, liposomes, nanoparticles, polymers, micelles, etc., within the limits of nanotechnology may also provide novel applications going beyond antimicrobial chemotherapy.

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