• Yan-Yan Li, Hui Wang, Jin Qian, Hyun Jun Kim, Jing-Jing Wu, Lian-Sheng Wang, Chuan-Wei Zhou, Zhi-Jian Yang, and Xin-Zheng Lu.
• Department of Geriatrics Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Physiology, University of Cincinnati, Cincinnati, OH Department of Nephrology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
• Medicine (Baltimore). 2017 Mar 1; 96 (12): e6461e6461.

BackgroundMyeloperoxidase (MPO) -463G/A gene polymorphism may be associated with an increased risk of developing coronary artery disease (CAD). Studies on the subject, however, do not provide a clear consensus. This meta-analysis was performed to explore the relationship between MPO gene -463G/A polymorphism and CAD risk.MethodsThis meta-analysis combines data from 4744 subjects from 9 independent studies. By using fixed or random effect models, the pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were assessed.ResultsOur analysis found a significant association between MPO gene -463G/A polymorphism and CAD in the whole population under all genetic models: allelic (OR: 0.68, 95% CI: 0.54-0.85, P = 0.0009), recessive (OR: 0.41, 95% CI: 0.22-0.76, P = 0.005), dominant (OR: 0.682, 95% CI: 0.534-0.871, P = 0.002), homozygous (OR: 0.36, 95% CI: 0.16-0.79, P = 0.01), heterozygous genetic model (OR: 0.832, 95% CI: 0.733-0.945, P = 0.004), and additive (OR: 0.64, 95% CI: 0.46-0.90, P = 0.01), especially in the Chinese subgroup (P < 0.05). On the contrary, we found no such relationship in the non-Chinese subgroup (P > 0.05).ConclusionThe MPO gene -463G/A polymorphism is associated with CAD risk, especially within the Chinese population. The A allele of MPO gene -463G/A polymorphism might protect the people from suffering the CAD risk.

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