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- P Brissot, E Bardou-Jacquet, M Latournerie, M Ropert-Bouchet, M L Island, O Loréal, and A-M Jouanolle.
- Inserm U-522, Service des Maladies du Foie, Centre de Dépistage des Surcharges en fer Rares d'Origine Génétique, CHU Pontchaillou, 2 rue Henri-Le-Guilloux, 35033 Rennes cedex 13, France. pierre.brissot@univ-rennes1.fr
- Pathol. Biol. 2010 Oct 1; 58 (5): 316-23.
AbstractThe field of hereditary iron overload has known, in the recent period, deep changes mainly related to major advances in molecular biology. It encompasses now a series of genetic entities. The mechanistic understanding of iron overload development and iron toxicity has greatly improved. The diagnostic approach has become essentially noninvasive with a major role for biological tests. From the therapeutic viewpoint, the phlebotomy treatment is now enriched by the possibility of resorting to oral chelation and by innovative perspectives directly linked to our improvement in the molecular understanding of these diseases.Copyright © 2009 Elsevier Masson SAS. All rights reserved.
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