• Pradipta Bhakta, Bablu Rani Ghosh, Umesh Singh, Preeti S Govind, Abhinav Gupta, Kulwant Singh Kapoor, Rajesh Kumar Jain, Tulsi Nag, Dipanwita Mitra, Manjushree Ray, Vikash Singh, and Gauri Mukherjee.
• Department of Anesthesiology and Intensive Care, University Hospital Kerry, Tralee, Ireland. Electronic address: bhaktadr@hotmail.com.
• Acta Anaesthesiol Taiwan. 2016 Dec 1; 54 (4): 108-113.

ObjectiveTo determine the safety, efficacy, and feasibility of propofol-based anesthesia in gynecological laparoscopies in reducing incidences of postoperative nausea and vomiting compared to a standard anesthesia using thiopentone/isoflurane.DesignRandomized single-blind (for anesthesia techniques used) and double-blind (for postoperative assessment) controlled trial.SettingOperation theater, postanesthesia recovery room, teaching hospital.PatientsSixty ASA (American Society of Anesthesiologists) I and II female patients (aged 20-60 years) scheduled for gynecological laparoscopy were included in the study.InterventionsPatients in Group A received standard anesthesia with thiopentone for induction and maintenance with isoflurane-fentanyl, and those in Group B received propofol for induction and maintenance along with fentanyl. All patients received nitrous oxide, vecuronium, and neostigmine/glycopyrrolate. No patient received elective preemptive antiemetic, but patients did receive it after more than one episode of vomiting.MeasurementsAssessment for incidence of postoperative nausea and vomiting as well as other recovery parameters were carried out over a period of 24 hours.Main ResultsSix patients (20%) in Group A and seven patients (23.3%) in Group B experienced nausea. Two patients (6.66%) in Group B had vomiting versus 12 (40%) in Group A (p<0.05). Overall, the incidence of emesis was 60% and 30% in Groups A and B, respectively (p<0.05). All patients in Group B had significantly faster recovery compared with those in Group A. No patient had any overt cardiorespiratory complications.ConclusionPropofol-based anesthesia was associated with significantly less postoperative vomiting and faster recovery compared to standard anesthesia in patients undergoing gynecological laparoscopy.Copyright © 2016. Published by Elsevier B.V.

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