• Krzysztof Skladowski, Marcin Hutnik, Andrzej Wygoda, Maria Golen, Boleslaw Pilecki, Wieslawa Przeorek, Tomasz Rutkowski, Beata Lukaszczyk-Widel, Alicja Heyda, Rafal Suwinski, Rafal Tarnawski, and Boguslaw Maciejewski.
• Maria Sklodowska-Curie Memorial Cancer Center and the Institute of Oncology, Branch in Gliwice, Poland. skladowski@io.gliwice.pl
• Int. J. Radiat. Oncol. Biol. Phys. 2013 Mar 1; 85 (3): 741-6.

PurposeTo report long-term results of randomized trial comparing 2 accelerated fractionations of definitive radiation therapy assessing the need to irradiate during weekend in patients with head and neck squamous cell carcinoma.Methods And MaterialsA total of 345 patients with SCC of the oral cavity, larynx, and oro- or hypo-pharynx, stage T2-4N0-1M0, were randomized to receive continuous accelerated irradiation (CAIR: once per day, 7 days per week) or concomitant accelerated boost (CB: once per day, 3 days per week, and twice per day, 2 days per week). Total dose ranged from 66.6-72 Gy, dose per fraction was 1.8 Gy, number of fractions ranged from 37-40 fractions, and overall treatment time ranged from 37-40 days.ResultsNo differences for all trial end-points were noted. At 5 and 10 years, the actuarial rates of local-regional control were 63% and 60% for CAIR vs 65% and 60% for CB, and the corresponding overall survival were 40% and 25% vs 44% and 25%, respectively. Confluent mucositis was the main acute toxicity, with an incidence of 89% in CAIR and 86% in CB patients. The 5-year rate of grade 3-4 late radiation morbidity was 6% for both regimens.ConclusionsResults of this trial indicate that the effects of accelerated fractionation can be achieve by delivering twice-per-day irradiation on weekday(s). This trial has also confirmed that an accelerated, 6-weeks schedule is a reasonable option for patients with intermediate-stage head-and-neck squamous cell carcinoma because of the associated high cure rate and minimal severe late toxicity.Copyright © 2013 Elsevier Inc. All rights reserved.

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