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Ugeskrift for laeger · Oct 2007
Review[Vitamin D insufficiency--possible etiologic factor of autoimmune diseases].
- JørgensenSøren PeterSPArhus Universitetshospital, Arhus Sygehus, Medicinsk Hepato-gastroenterologisk Afdeling V. spgjo@as.aaa.dk, Lars Erik Bartels, Jørgen Agnholt, Henning Glerup, Søren Lyhne Nielsen, Christian Lodberg Hvas, and Jens F Dahlerup.
- Arhus Universitetshospital, Arhus Sygehus, Medicinsk Hepato-gastroenterologisk Afdeling V. spgjo@as.aaa.dk
- Ugeskr. Laeg. 2007 Oct 22; 169 (43): 3655-60.
AbstractThe primary source of vitamin D in humans is sun exposure to the skin. The incidence of certain autoimmune diseases correlates positively with latitude. As vitamin D production increases with sun exposure, vitamin D insufficiency is hypothesised to influence the development of autoimmune diseases. In experimental animal and cellular studies in vitro 1.25-(OH)2-vitamin D reduces inflammation. This article discusses the role of vitamin D in inflammatory bowel disease, type 1 diabetes mellitus, multiple sclerosis, and rheumatoid arthritis.
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