• Diagn. Microbiol. Infect. Dis. · Oct 2013

    Multicenter Study

    Performance of cobas® 4800 and m2000 real-time™ assays for detection of Chlamydia trachomatis and Neisseria gonorrhoeae in rectal and self-collected vaginal specimen.

    • Tanja H Geelen, John W Rossen, Antoine M Beerens, Linda Poort, Servaas A Morré, Wilma S Ritmeester, Harry E van Kruchten, Masja M van de Pas, and Paul H M Savelkoul.
    • Department of Medical Microbiology, University Medical Center Maastricht, The Netherlands.
    • Diagn. Microbiol. Infect. Dis. 2013 Oct 1;77(2):101-5.

    AbstractA prospective, multicenter trial was designed to compare the performance characteristics of the cobas® 4800 (Roche Diagnostics, Indianapolis, IN, USA) and m2000 real-time™ (Abbott Molecular Inc., Des Plaines, IL, USA) assays for detection of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in rectal and self-collected vaginal swabs. Rectal (n = 234) or self-collected vaginal swabs (n = 687) were obtained from consenting individuals visiting their general practitioners, dermatologists, gynecologists, sexually transmitted disease clinics, or family planning centers from May 2010 to February 2011. High concordance rates (≥96%) were observed between the cobas® 4800 and m2000 real-time™ assays for CT/NG detection in both rectal and self-collected vaginal swabs. The performance profiles confirm the usefulness of both kinds of swab types for CT and NG detection using described nucleic acid amplification tests assays. Based on this study, rectal and self-collected vaginal swabs offer a noninvasive alternative, which may improve screening for CT and NG infections.© 2013.

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