• Saransh Jain, Rajesh Padhan, Sawan Bopanna, Sushil Kumar Jain, Rajan Dhingra, Nihar Ranjan Dash, Kumble Seetharama Madhusudan, Shivanand Ramachandra Gamanagatti, Peush Sahni, and GargPramod KumarPKDepartment of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India. pgarg10@gmail.com..
• Department of Gastroenterology, All India Institute of Medical Sciences, New Delhi, India.
• Dig. Dis. Sci. 2020 Feb 1; 65 (2): 615-622.

BackgroundInfected pancreatic necrosis (IPN) is a major complication of acute pancreatitis (AP), which may require necrosectomy. Minimally invasive surgical step-up therapy is preferred for IPN.AimTo assess the effectiveness of percutaneous endoscopic step-up therapy in patients with IPN and identify predictors of its success.MethodsConsecutive patients with AP hospitalized to our tertiary care academic center were studied prospectively. Patients with IPN formed the study group. The treatment protocol for IPN was percutaneous endoscopic step-up approach starting with antibiotics and percutaneous catheter drainage, and if required necrosectomy. Percutaneous endoscopic necrosectomy (PEN) was performed using a flexible endoscope through the percutaneous tract under conscious sedation. Control of sepsis with resolution of collection(s) was the primary outcome measure.ResultsA total of 415 patients with AP were included. Of them, 272 patients had necrotizing pancreatitis and 177 (65%) developed IPN. Of these 177 patients, 27 were treated conservatively with antibiotics alone, 56 underwent percutaneous drainage alone, 53 required underwent PEN as a step-up therapy, 1 per-oral endoscopic necrosectomy, and 52 required surgery. Of the 53 patients in the PEN group, 42 (79.2%) were treated successfully-34 after PEN alone and 8 after additional surgery. Eleven of 53 patients died due to organ failure-7 after PEN and 4 after surgery. Independent predictors of mortality were > 50% necrosis and early organ failure.ConclusionPercutaneous endoscopic step-up therapy is an effective strategy for IPN. Organ failure and extensive pancreatic necrosis predicted a suboptimal outcome in patients with infected necrotizing pancreatitis.

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