• Linda Knutsson, Emelie Lindgren, André Ahlgren, Matthias J P van Osch, Markenroth BlochKarinK, Yulia Surova, Freddy Ståhlberg, Danielle van Westen, and Ronnie Wirestam.
• Department of Medical Radiation Physics, Lund University, Lund, Sweden.
• J Magn Reson Imaging. 2015 Apr 1; 41 (4): 903-8.

PurposeTo evaluate and mutually compare the tail-scaling approach and the prebolus administration concept for reduction of arterial partial volume effects (PVEs), because reproducible absolute quantification of cerebral blood flow (CBF) by dynamic susceptibility contrast magnetic resonance imaging (MRI) is often hampered by PVEs in the arterial input function (AIF) registration.Materials And MethodsTwenty healthy volunteers were scanned in a test-retest study with 7-20 days between investigations to examine the quantitative values and the repeatability of CBF estimates obtained from the tail-scaling and the prebolus administration approaches.ResultsAverage grey matter CBF was 80 ± 18 mL/100 g/min (mean ± SD) using tail-scaling and 56 ± 18 mL/100 g/min using prebolus administration. The intraclass correlation coefficient was 0.52 for the tail-scaling approach and 0.86 for the prebolus administration concept.ConclusionBoth correction methods resulted in considerably reduced arterial PVEs, leading to quantitative estimates of perfusion approaching those typically obtained by other perfusion modalities. The CBF estimates obtained using the prebolus administration concept showed superior repeatability. Potential sources of uncertainty in the tail-scaling approach include the use of venous concentration curves influenced by PVEs or by geometric distortions (ie, vessel pixel shifts) in the steady-state period.© 2014 Wiley Periodicals, Inc.

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