• Eur. J. Pharmacol. · Aug 1993

    Conventionalization of germ-free rats reverses the disability of rhein anthrone to induce laxation.

    • G Nijs, P De Witte, K Geboes, J Mertens, and H Eyssen.
    • Laboratory of Pharmaceutical Biology and Phytopharmacology, Institute of Pharmaceutical Sciences, K.U. Leuven, Belgium.
    • Eur. J. Pharmacol. 1993 Aug 3; 239 (1-3): 241-3.

    AbstractThis study shows that rhein anthrone has no laxative potency in germ-free rats because after intracaecal administration of a dose of 50 mg/kg the large intestine transit exceeded 240 min. The time course of the laxative potency of rhein anthrone injected intracaecally was evaluated after peroral inoculation of germ-free rats with the caecal contents of conventional rats. Large intestine transit was measured at consecutive periods, on days 0, 1, 2, 3 and 5 after peroral inoculation. It appeared that 1 day after peroral inoculation the laxative potency of rhein anthrone was already established (large intestinal transit < 10 min) and laxation remained on the following days (days 2, 3 and 5). We concluded that rhein anthrone is inactive in germ-free rats and acquires laxative potency after peroral inoculation of germ-free rats with caecal contents of conventional rats.

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