• Medicina · Jun 2021

    Case Reports

    Topical 5% Imiquimod Sequential to Surgery for HPV-Related Squamous Cell Carcinoma of the Lip.

    • Giovanni Pentangelo, Steven Paul Nisticò, Eugenio Provenzano, Giusy Ylenia Cisale, and Luigi Bennardo.
    • Unit of Oral Surgery, Polla Hospital, 84035 Polla, Italy.
    • Medicina (Kaunas). 2021 Jun 2; 57 (6).

    BackgroundSquamous cell carcinoma (SCC) is one of the most common neoplasms affecting the oral cavity and the face. Its more differentiated forms may be associated with human papilloma virus (HPV) infection.Case ReportIn this paper, we report the case of an 86-year-old patient with a well-differentiated SCC of the lower lip associated with HPV treated with surgery with a non-complete histological resolution. Imiquimod 5% cream was applied on the surgical scar once a day for two weeks and then once a week. Two years after SCC removal, no relapse has occurred.ConclusionsTopical imiquimod may be a safe and effective treatment after surgery in SCC of the oral area to reduce the risk of relapses.

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