• Emanuela Sozio, Alessio Bertini, Giacomo Bertolino, Francesco Sbrana, Andrea Ripoli, Fabio Carfagna, Alessandro Giacinta, Bruno Viaggi, Simone Meini, Lorenzo Ghiadoni, and Carlo Tascini.
• Infectious Disease Unit, Azienda Sanitaria Universitaria Integrata di Udine (ASU FC), 33100 Udine, Italy.
• Medicina (Kaunas). 2021 Jun 12; 57 (6).

AbstractBackground and Objectives: Chances of surviving sepsis increase markedly upon prompt diagnosis and treatment. As most sepsis cases initially show-up in the Emergency Department (ED), early recognition of a septic patient has a pivotal role in sepsis management, despite the lack of precise guidelines. The aim of this study was to identify the most accurate predictors of in-hospital mortality outcome in septic patients admitted to the ED. Materials and Methods: We compared 651 patients admitted to ED for sepsis (cases) with 363 controls (non-septic patients). A Bayesian mean multivariate logistic regression model was performed in order to identify the most accurate predictors of in-hospital mortality outcomes in septic patients. Results: Septic shock and positive qSOFA were identified as risk factors for in-hospital mortality among septic patients admitted to the ED. Hyperthermia was a protective factor for in-hospital mortality. Conclusions: Physicians should bear in mind that fever is not a criterium for defining sepsis; according to our results, absence of fever upon presentation might be indicative of greater severity and diagnosis of sepsis should not be delayed.

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