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- Bridget F Koontz and W Robert Lee.
- Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina 27710, USA.
- Arch. Esp. Urol. 2011 Oct 1; 64 (8): 858-64.
AbstractAndrogen deprivation plays a major role in the treatment of prostate cancer.Preclinical studies have shown that androgen deprivation provides both an independent cytotoxic effect and radiosensitization on prostate tumors. For men with non-metastatic prostate cancer, the addition of androgen deprivation to radiotherapy has been shown to improve survival for intermediate and high risk disease compared to radiation alone.This review discusses the clinical trial data regarding combination of androgen deprivation and radiation and provides recommendations for its use in men undergoing radiotherapy for localized prostate cancer.
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