• Future oncology · Jun 2018

    Review

    The role of nivolumab in melanoma.

    • Fabio Gomes, Patricio Serra-Bellver, and Paul Lorigan.
    • The Christie NHS Foundation Trust, Manchester, UK.
    • Future Oncol. 2018 Jun 1; 14 (13): 1241-1252.

    AbstractThe incidence of melanoma continues to rise worldwide. Prior to 2010, there had been no progress in the treatment of advanced melanoma in living memory. Since then, immunotherapy has become a standard of care in the treatment of advanced melanoma. Nivolumab is a fully human monoclonal antibody against PD-1, which is a negative regulatory checkpoint in the T cells. The clinical benefit of nivolumab as a single agent is well established, with response rates of ≥40%, durable responses and a favorable tolerability profile. The combination of nivolumab and ipilimumab has also become a standard of care and the role of nivolumab in the adjuvant setting for high-risk patients has been recently confirmed.

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