• Fubin Xiao, Wei Han, Qing Yue, Jianji Ke, Baoxing Jia, and Xiaojuan Fu.
• Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of BeiHua University, Jilin, Jilin, P.R. China.
• Medicine (Baltimore). 2021 Jul 9; 100 (27): e25743e25743.

IntroductionThe effect of perioperative omega-3 fatty acids for liver surgery remained controversial. We conducted a systematic review and meta-analysis to explore the influence of omega-3 fatty acids versus placebo in patients undergoing liver surgery.MethodsWe have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through May 2020, and included randomized controlled trials (RCTs) assessing the effect of omega-3 fatty acids versus placebo for liver surgery. This meta-analysis was performed using the random-effect model.ResultsFive RCTs were included in the meta-analysis. Overall, compared with control group for liver surgery, omega-3 fatty acids were associated with substantially reduced incidence of infection (odd ratio [OR]=0.56; 95% confidence interval [CI] =0.34-0.91; P = .02), but revealed no remarkable influence on complications (OR = 0.60; 95% CI = 0.29-1.24; P = .17), mortality (OR = 0.76; 95% CI = 0.06-9.37; P = .83), liver failure (OR = 0.72; 95% CI = 0.10 to 5.00; P = 0.74), biliary leakage (OR=1.24; 95% CI = 0.41 to 3.76; P = .70), bleeding (OR = 1.76; 95% CI = 0.63-4.95; P = .28), or ileus (OR = 0.39; 95% CI = 0.07-2.05; P = .27).ConclusionPerioperative omega-3 fatty acids may be beneficial to reduce the incidence of infection after liver surgery.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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