• Yingpu Yuan, Xiaobo Zhang, and Chunmei Gui.
• Department of Critical Care Medicine.
• Medicine (Baltimore). 2021 Jul 9; 100 (27): e26514e26514.

RationaleChlamydia psittaci (C psittaci) is a gram-negative obligate intracellular parasite, with birds as main hosts. The main route of infection in humans is inhalation of aerosols from contaminated animal excreta through the respiratory tract. The main manifestation of C psittaci infection is pneumonia. Patients suffering from severe infection are prone to sepsis and multiple organ failure. We report a case of simultaneous detection of C psittaci in blood and bronchoalveolar lavage fluid using metagenomic next-generation sequencing (mNGS) technology.Patient ConcernsThe 71-year-old male patient was a farmer with a long history of raising poultry and initial symptoms of fever and muscle pain accompanied by limb weakness and paroxysmal cough.DiagnosesThe patient was diagnosed with sepsis, severe pneumonia, and multiple organ failure.InterventionsAnti-infective therapy with doxycycline and meropenem was applied.OutcomesThe patient's body temperature and infection indicators improved and the chest X-ray findings showed the amelioration of lesions after 18 days of treatment. The patient was discharged without treatment on hospital day 19 due to financial constraints and subsequently died after 7 days.LessonsmNGS is an excellent diagnostic tool when specific pathogens are undetected by traditional assays.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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