• Wooram Bae, Seongmin Kim, Jungyoon Choi, Tae Won Lee, Eunjin Bae, Ha Nee Jang, Sehyun Jung, Seunghye Lee, Se-Ho Chang, and Dong Jun Park.
• Department of Internal Medicine, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
• Medicine (Baltimore). 2021 Jul 9; 100 (27): e26606e26606.

RationaleMomordica charantia is often used to treat type 2 diabetes mellitus in Korea. Drug-induced acute interstitial nephritis (AIN) accounts for 60% to 70% of AIN cases. However, only 1 case of AIN associated with ingesting M charantia has been reported in the English literature. We report an extremely rare case of AIN that occurred after a patient ingested a pure M charantia extract over 7 months.Patient ConcernsA 60-year-old Korean woman was admitted to our hospital for a renal biopsy. Her renal function had decreased gradually over the last 9 months without symptoms or signs.DiagnosisHer blood urea nitrogen and serum creatinine levels were 29.7 mg/dL (range: 8.0-20.0 mg/dL) and 1.45 mg/dL (range: 0.51-0.95 mg/dL) on admission. Renal histology indicated AIN; there was immune cell infiltration into the interstitium, tubulitis, and epithelial casts, although the glomeruli were largely intact.InterventionsM charantia was discontinued and prednisolone was prescribed.OutcomesThe value of serum creatinine has almost been restored to the baseline level after 3 months.Conclusions: This is the first case report of AIN associated with the ingestion of a pure M charantia extract. Recognition of the possible adverse effects of these agents by physicians is very important for early diagnosis and appropriate management.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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