-
Review
A/J mouse as a model for lung tumorigenesis caused by tobacco smoke: strengths and weaknesses.
- Hanspeter Witschi.
- Center for Health and Environment, University of California, Davis, CA 95616, USA. hrwitschi@ucdavis.edu
- Exp. Lung Res. 2005 Jan 1; 31 (1): 3-18.
AbstractStrain A/J mice have successfully been used to develop an animal model for tobacco smoke carcinogenesis. In 18 individual studies, reported by 4 different laboratories, a significant increase in lung tumor multiplicities following exposure from 50 to 170mg/m3 of total suspended tobacco smoke particulates was found in 15 studies (83 %) and a significant increase in lung tumor incidence in 10 studies (56%). However, tumor multiplicities are comparatively low (from an average of 1.1 to 2.8 tumors per lung). From a toxicological standpoint, this indicates that cigarette smoke is a weak animal carcinogen. Although the assay allowed one to detect substantial chemopreventive activity of a mixture of myo-inositol and dexamethasone, it was less successful in showing efficacy for several other agents.
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