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Best Pract Res Clin Haematol · Dec 2017
ReviewWhich new agents will be incorporated into frontline therapy in acute myeloid leukemia?
- Richard M Stone.
- Harvard Medical School, Boston, MA 02215, USA; Adult Leukemia Program, Dana-Farber Cancer Institute, 450 Brookline Avenue, D2053, Boston, MA 02215, USA. Electronic address: rstone@partners.org.
- Best Pract Res Clin Haematol. 2017 Dec 1; 30 (4): 312-316.
AbstractFor 4 decades, new agents had not been permanently approved for use in treating acute myeloid leukemia (AML). The long dry spell was broken in 2017, however, with the approval of several agents: midostaurin for addition to chemotherapy in mutant FLT3 patients undergoing intensive chemotherapy, enasidenib in advanced mutant IDH2 patients, CPX-351 in secondary AML patients, and gemtuzumab ozogamicin in conjunction with standard chemotherapy in AML. This review surveys the use of tyrosine kinase inhibitors to treat patients with mutant FLT3 AML, mutant KIT AML, as well as IDH inhibitors and explores some questions regarding their integration into the treatment armamentarium for AML.Copyright © 2017. Published by Elsevier Ltd.
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