• Semin Oncol Nurs · Nov 2000

    Review

    Development and clinical overview of trastuzumab (herceptin).

    • C Frankel.
    • Comprehensive Cancer Research Group/Intercenter Cancer Research Group, Mount Sinai Comprehensive Cancer Center, Miami Beach, FL, USA.
    • Semin Oncol Nurs. 2000 Nov 1; 16 (4 Suppl 1): 13-7.

    ObjectivesTo provide a review of the two pivotal clinical trials evaluating trastuzumab in metastatic breast cancer, either in combination with chemotherapy or as a single agent.Data SourcesResearch reports.ConclusionsTrastuzumab is indicated as a single agent or in combination with chemotherapy for patients with metastatic breast cancer who overexpress the HER2 protein. The toxicity profile of trastuzumab is favorable; cardiac dysfunction has been the primary dose-limiting toxicity, especially when combined with anthracyclines.Implications For Nursing PracticeNurses will deliver trastuzumab in the clinical setting and must be familiar with its efficacy and toxicity profile.

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