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Dermatologic therapy · Sep 2010
Case ReportsTherapeutic hotline. Infliximab for treatment of resistant pyoderma gangrenosum associated with ulcerative colitis and psoriasis. A case report.
- Francesco Baglieri and Giovanni Scuderi.
- Department of Dermatology, S. Elia Hospital, Via Luigi Russo 6, Caltanissetta (CL), Italy. francbag@tiscali.it
- Dermatol Ther. 2010 Sep 1; 23 (5): 541-3.
AbstractPyoderma gangrenosum (PG) is a rare, noninfectious, neutrophilic dermatosis of unknown origin that is associated with systemic diseases in 50% of cases. The authors present a case of a 54-year-old man patient with refractory to conventional treatment PG associated with ulcerative colitis and psoriasis, which showed a successful response to treatment with infliximab, a chimeric monoclonal antibody that inhibits tumor necrosis factor alpha (TNF-α). This case report shows the frequent difficulty in the therapeutic approach of PG, especially if associated with underlying disease, and necessity to apply new agents, such as a novel application of the TNF-α inhibitors, in relationship to the recent pathogenic knowledge.© 2010 Wiley Periodicals, Inc.
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