-
Pediatr Hematol Oncol · Mar 2008
Case ReportsAnaphylactoid reaction to high-dose methotrexate and re-administration after a successful desensitization.
- Teresa Caldeira, Vitor Costa, Isabel Silva, Tereza Oliva, and Lucília Norton.
- Department of Paediatrics, Centro Hospitalar Vila Nova de Gaia, Vila Nova de Gaia, Portugal.
- Pediatr Hematol Oncol. 2008 Mar 1; 25 (2): 131-4.
AbstractMethotrexate (MTX) is an antimetabolite with a major role in the treatment of acute lymphoblastic leukaemia (ALL). The authors report the management of a 9-year-old boy who developed an anaphylactoid reaction to high-dose MTX infusion, after a first challenge with intrathecal administration, during induction therapy for ALL. A desensitization protocol was followed and MTX tolerance has been successfully achieved, allowing this patient to complete the needed chemotherapy.
Notes
Knowledge, pearl, summary or comment to share?You can also include formatting, links, images and footnotes in your notes
- Simple formatting can be added to notes, such as
*italics*,_underline_or**bold**. - Superscript can be denoted by
<sup>text</sup>and subscript<sub>text</sub>. - Numbered or bulleted lists can be created using either numbered lines
1. 2. 3., hyphens-or asterisks*. - Links can be included with:
[my link to pubmed](http://pubmed.com) - Images can be included with:
 - For footnotes use
[^1](This is a footnote.)inline. - Or use an inline reference
[^1]to refer to a longer footnote elseweher in the document[^1]: This is a long footnote..