• Annual review of medicine · Jan 2002

    Review

    Recent advancements in the treatment of chronic myelogenous leukemia.

    • Michael E O'Dwyer, Michael J Mauro, and Brian J Druker.
    • Leukemia Center, Oregon Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, Portland, Oregon 97201, USA. odwyerm@ohsu.edu
    • Annu. Rev. Med. 2002 Jan 1; 53: 369-81.

    AbstractChronic myelogenous leukemia (CML) is a clonal hematopoetic stem cell disorder characterized by the Philadelphia chromosome and resultant production of the constitutively activated Bcr-Abl tyrosine kinase. Characterized clinically by marked myeloid proliferation, it invariably terminates in an acute leukemia. Conventional therapeutic options include interferon-based regimens and stem cell transplantation, with stem cell transplantation being the only curative therapy. Through rational drug development, STI571, a Bcr-Abl tyrosine kinase inhibitor, has emerged as a paradigm for gene product targeted therapy, offering new hope for expanded treatment options for patients with CML.

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