• Foro ArnalotPalmiraPRadiation Oncology Department, Hospital de l'Esperança, Barcelona, Spain. pforo@imas.imim.es, Agustí Valls Fontanals, Joan Carles Galcerán, Frances Lynd, Xavier Sanz Latiesas, Nuria Rodríguez de Dios, Anna Reig Castillejo, Marti Lacruz Bassols, Joan Lozano Galán, Ismael Membrive Conejo, and Manuel Algara López.
• Radiation Oncology Department, Hospital de l'Esperança, Barcelona, Spain. pforo@imas.imim.es
• Radiother Oncol. 2008 Nov 1; 89 (2): 150-5.

Background And PurposeThe aim was to demonstrate similar pain relief with two schedules of radiotherapy for painful bone metastases.Materials And MethodsA total of 160 patients were assigned to receive a single 8-Gy fraction or 30 Gy in 10 fractions. Pain intensity was measured on an ordinal pain scale of 0-10. Partial response was defined as a pain reduction of two points or more and complete response as a pain score of zero at the treated area. Response follow-up was at 3, 12, 24 and 48 weeks.ResultsThe overall response was 75% in the 8-Gy arm and 86% in the 30-Gy arm. Complete response and partial response rates were 15% and 60% in the 8-Gy arm, 13% and 73% in the 30-Gy arm. Acute toxicity was of 18% in the 30-Gy arm and of 12% in the 8-Gy arm. These differences were not statistically significant. The re-treatment rate was 28% vs 2% in the 8-Gy and 30-Gy arms, respectively, these were statistically significant.ConclusionsA single-fraction regimen of 8 Gy was as safe and effective as a multifraction regimen of 30 Gy for painful bone metastases in terms of pain relief.

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