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Thoracic surgery clinics · May 2009
Treatment of heterogeneous emphysema using the spiration IBV valves.
- Steven C Springmeyer, Chris T Bolliger, Thomas K Waddell, Xavier Gonzalez, Douglas E Wood, and IBV Valve Pilot Trials Research Teams.
- School of Medicine, University of Washington, Seattle, WA, USA. sspringmeyer@spiration.com
- Thorac Surg Clin. 2009 May 1; 19 (2): 247-53, ix-x.
AbstractNinety-eight emphysema patients were treated at 13 international sites during a 3-year series of single-arm, open-label studies with the IBV valve and a multi-lobar treatment approach. Fifty six percent of subjects had a clinically meaningful improvement in health-related quality of life, but standard pulmonary function and exercise studies were insensitive effectiveness measures. Quantitative CT analyses of regional lung changes showed lobar volume changes in over 85% of subjects. Lung volume reduction was an uncommon mechanism for a treatment response with bilateral upper lobe treatment. A redirection of inspired air, an interlobar shift to health-ier lung tissue, was the most common mechanism for a valve treatment response.
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