• Emanuela Formaggio, Silvia Francesca Storti, Mirko Avesani, Roberto Cerini, Franco Milanese, Anna Gasparini, Michele Acler, Roberto Pozzi Mucelli, Antonio Fiaschi, and Paolo Manganotti.
• Section of Neurological Rehabilitation, Department of Neurological and Visual Sciences, Gianbattista Rossi Hospital, University of Verona, P.le Scuro, 37134, Verona, Italy. formaggio@dei.unipd.it
• Brain Topogr. 2008 Dec 1; 21 (2): 100-11.

AbstractElectroencephalography combined with functional magnetic resonance imaging (EEG-fMRI) may be used to identify blood oxygenation level dependent (BOLD) signal changes associated with physiological and pathological EEG event. In this study we used EEG-fMRI to determine the possible correlation between topographical movement-related EEG changes in brain oscillatory activity recorded from EEG electrodes over the scalp and fMRI-BOLD cortical responses in motor areas during finger movement. Thirty-two channels of EEG were recorded in 9 subjects during eyes-open condition inside a 1.5 T magnetic resonance (MR) scanner using a MR-compatible EEG recording system. Off-line MRI artifact subtraction software was applied to obtain continuous EEG data during fMRI acquisition. For EEG data analysis we used the event-related-synchronization/desynchronization (ERS/ERD) approach to investigate where movement-related decreases in alpha and beta power are located. For image statistical analysis we used a general linear model (GLM) approach. There was a significant correlation between the positive-negative ratio of BOLD signal peaks and ERD values in the electrodes over the region of activation. We conclude that combined EEG-fMRI may be used to investigate movement-related oscillations of the human brain inside an MRI scanner and the movement-related changes in the EMG or EEG signals are useful to identify the brain activation sources responsible for BOLD-signal changes.

34 keywords...

hide…