• IEEE Trans Biomed Eng · Jan 2008

    Atlas-based indexing of brain sections via 2-D to 3-D image registration.

    • Smadar Gefen, Nahum Kiryati, and Jonathan Nissanov.
    • PVI Virtual Media Services LLC, 15 Princess Road, Lawrenceville, NJ 08648, USA. sgefen@pvi.tv
    • IEEE Trans Biomed Eng. 2008 Jan 1; 55 (1): 147-56.

    AbstractA 2-D to 3-D nonlinear intensity-based registration method is proposed in which the alignment of histological brain sections with a volumetric brain atlas is performed. First, sparsely cut brain sections were linearly matched with an oblique slice automatically extracted from the atlas. Second, a planar-to-curved surface alignment was employed in order to match each section with its corresponding image overlaid on a curved-surface within the atlas. For the latter, a PDE-based registration technique was developed that is driven by a local normalized-mutual-information similarity measure. We demonstrate the method and evaluate its performance with simulated and real data experiments. An atlas-guided segmentation of mouse brains' hippocampal complex, retrieved from the Mouse Brain Library (MBL) database, is demonstrated with the proposed algorithm.

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