We report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.
Terance Hart, Alba T Macias, Karen Benwell, Teresa Brooks, Jalanie D'Alessandro, Pawel Dokurno, Geraint Francis, Ben Gibbons, Timothy Haymes, Guy Kennett, Sean Lightowler, Howard Mansell, Natalia Matassova... more , Anil Misra, Anthony Padfield, Rachel Parsons, Robert Pratt, Alan Robertson, Steven Walls, Melanie Wong, and Stephen Roughley. less
Vernalis (R&D) Ltd, Granta Park, Cambridge CB21 6GB, UK. t.hart@vernalis.com
Bioorg. Med. Chem. Lett. 2009 Aug 1; 19 (15): 4241-4.
AbstractWe report the discovery of a novel, chiral azetidine urea inhibitor of Fatty Acid Amide Hydrolase (FAAH,) and describe the surprising species selectivity of VER-156084 versus rat and human FAAH and also hCB1.