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Journal of neurosurgery · Jun 1984
Case ReportsAcute nonlymphocytic leukemia following treatment of malignant glioma. Report of two cases.
- S Kempin, N Sundaresan, W B Shapiro, and Z Arlin.
- J. Neurosurg. 1984 Jun 1; 60 (6): 1287-90.
AbstractTwo patients with malignant brain tumors who developed acute nonlymphocytic leukemia after treatment with radiation and chemotherapy are described. Both patients survived more than 2 years after diagnosis of the brain tumor. Survival following the diagnosis of leukemia was short, and both patients died of hemorrhage secondary to thrombocytopenia. A review of the literature reveals that leukemia after combined-modality treatment of malignant brain tumors is rare. A prolonged survival period from diagnosis of the primary tumor, treatment with nitrosoureas and radiation, plus the development of a preleukemic myelodysplastic syndrome are all important features of therapy-related nonlymphocytic leukemia.
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