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Best Pract Res Clin Gastroenterol · Oct 2020
ReviewThe impact of modulating the gastrointestinal microbiota in cancer patients.
- Egidijus Morkūnas, Jurgita Skiecevičienė, and Juozas Kupčinskas.
- Department of Gastroenterology, Academy of Medicine, Lithuanian University of Health Sciences, Kaunas, Lithuania. Electronic address: eamorkunas@gmail.com.
- Best Pract Res Clin Gastroenterol. 2020 Oct 1; 48-49: 101700.
AbstractGastrointestinal microbiota is vastly deregulated in cancer patients due to different factors, but the exact mechanisms of interaction between cancer and microbiome are still poorly understood. Current evidence suggests that alterations in the composition of the microbiota may affect efficacy and toxicity of anti-cancer therapies. Recent preclinical and clinical studies demonstrate different mechanisms and outcomes of deregulation of gut microbiome, and investigate effects of modulating gastrointestinal microbiota in cancer patients. This paper reviews effects of altered microbiome on anti-cancer management, including antibiotics, chemotherapy and immunotherapy, as well as possible outcomes of modulating altered microbiome by probiotics or faecal microbiome transplantation in cancer patients.Copyright © 2020 Elsevier Ltd. All rights reserved.
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