• Respiratory investigation · Jan 2021

    Case Reports

    Two cases of chronic obstructive pulmonary disease with undetectable diffusing capacity for carbon monoxide.

    • Ayumi Ohara, Satoshi Konno, Kaoruko Shimizu, Masaru Suzuki, Masafumi Yamamoto, Asako Mitani, Mutsumi Nishida, Takanori Teshima, and Masaharu Nishimura.
    • Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, Sapporo, Hokkaido, Japan. Electronic address: aohara@huhp.hokudai.ac.jp.
    • Respir Investig. 2021 Jan 1; 59 (1): 145-148.

    AbstractPulmonary diffusing capacity for carbon monoxide (DLCO) is a valuable pulmonary function test to evaluate the gas exchange capacity of the lungs. Generally, DLCO values are significantly lower in patients with chronic obstructive pulmonary disease (COPD), particularly in those with a predominantly emphysema phenotype. However, it is extremely rare that DLCO values cannot be obtained for reasons other than technical errors. Herein, we report two patients with COPD in whom DLCO values were undetectable without prolonging the breath-holding time for the test. We discuss possible mechanisms for these peculiar findings.Copyright © 2020. Published by Elsevier B.V.

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