• Giovanni Grandi, Anna Myriam Perrone, Antonino Perrone, Vincenzo Dario Mandato, Giuseppe Comerci, Margaret Sammarini, Carla Merisio, Andrea Amadori, Marco Stefanetti, Ruby Martinello, Fabio Facchinetti, Pierandrea De Iaco, and Brca Emilia-Romagna Gyneco-Oncological (BERGO) Collaborative Group.
• Hereditary Breast-Ovarian Cancer Group, University of Modena and Reggio Emilia, Azienda Ospedaliero Universitaria Policlinico, Via del Pozzo 71, 41124, Modena, Italy. Electronic address: giovanni.grandi@unimore.it.
• Maturitas. 2021 Jan 1; 143: 59-64.

BackgroundBRCA1 mutation carriers are recommended to undergo prophylactic risk-reducing salpingo-oophorectomy (RRSO) between the ages of 35 and 40 or when child bearing is complete, with a possible delay until age 40-45 for BRCA2 mutation carriers.Study QuestionPrimary outcome was the rate of unsuspected cancer findings during RRSO in a region of northern Italy (Emilia Romagna) and secondary outcomes were details of RRSO: age at surgical intervention, the venue of the procedures in relation to the surgical/pathological quality and the rate/role of concomitant opportunistic hysterectomies.Study DesignMulticentre data collection by invitation to report current RRSO practices.ResultsA total of 222 RRSOs (54.5 % BRCA1, 34.7 % BRCA2, 1.8 % BRCA1 and BRCA2 combined, 5.8 % BRCA-VUS and 3.2 % BRCA not better specified) were reported from 9 different centres, half in non-university hospitals and the remainder in university hospitals. Breast cancer survivors (56.3 %) underwent the RRSO at a younger age (47.8 vs 50.6 years, p =  0.02). The mean and median ages at surgical intervention (49.0 and 48.0, respectively) were similar for BRCA1 and BRCA2 mutation carriers, as was the temporal trend in age distribution, and proportions treated in university and non-university hospitals. A diagnosis of ovarian invasive cancer was reported in 3.5 % of subjects, all BRCA1 or BRCA-combined subjects, at a median and mean age of 57 years (range 42-68). Abnormal tubal findings, such as serous tubal intraepithelial lesions (STIL) (100 %), secretory cell outgrowth (SCOUT) (100 %) and STIC (71.4 %), were mainly reported by pathologists in university hospitals. Of the 222 procedures, 15 (6.7 %) included hysterectomies: in none of these cases was a primitive uterine endometrioid or serous cancer found.ConclusionsThe results from this multicentre regional study should guide future preventive health policies for RRSO in BRCA mutation carriers.Copyright © 2020 Elsevier B.V. All rights reserved.

25 keywords...

hide…