• Magn Reson Med · Dec 2011

    Fast three-dimensional proton spectroscopic imaging of the human brain at 3 T by combining spectroscopic missing pulse steady-state free precession and echo planar spectroscopic imaging.

    • Wolfgang Dreher, Peter Erhard, and Dieter Leibfritz.
    • Fachbereich 2, Chemie, Universität Bremen, Bremen, Germany. wdreher@uni-bremen.de
    • Magn Reson Med. 2011 Dec 1; 66 (6): 1518-25.

    AbstractThe combination of the principles of two fast spectroscopic imaging (SI) methods, spectroscopic missing pulse steady-state free precession and echo planar SI (EPSI) is described as an approach toward fast 3D SI. This method, termed missing pulse steady-state free precession echo planar SI, exhibits a considerably reduced minimum total measurement time T(min), allowing a higher temporal resolution, a larger spatial matrix size, and the use of k-space weighted averaging and phase cycling, while maintaining all advantages of the original spectroscopic missing pulse steady-state free precession sequence. The minor signal-to-noise ratio loss caused by using oscillating read gradients can be compensated by applying k-space weighted averaging. The missing pulse steady-state free precession echo planar SI sequence was implemented on a 3 T head scanner, tested on phantoms and applied to healthy volunteers.Copyright © 2011 Wiley Periodicals, Inc.

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