• Adv. Drug Deliv. Rev. · May 2021

    Review

    Adaptive immune responses to SARS-CoV-2.

    • Donald Forthal.
    • Division of Infectious Diseases, Department of Medicine, Department of Molecular Biology and Biochemistry, University of California, Irvine School of Medicine and School of Biological Sciences, United States. Electronic address: dnfortha@uci.edu.
    • Adv. Drug Deliv. Rev. 2021 May 1; 172: 1-8.

    AbstractThis review focuses on adaptive immune responses against SARS-CoV-2, the coronavirus that causes COVID-19. A great deal of work has been accomplished in a very short period of time to describe adaptive immune responses and to ascertain their roles in determining the course of infection. As with other viral infections, SARS-CoV-2 elicits both antibody and T-cell responses. Whereas antibody responses are likely effective in preventing infection and may participate in controlling infection once established, it is less clear whether or not they play a role in pathogenesis. T cells are likely involved in controlling established infection, but a pathogenic role is also possible. Longer term evaluation is necessary to determine the durability of protective immune responses.Copyright © 2021 Elsevier B.V. All rights reserved.

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