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- Arezoo Hosseini, Vida Hashemi, Navid Shomali, Faezeh Asghari, Tohid Gharibi, Morteza Akbari, Saber Gholizadeh, and Abbas Jafari.
- Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, School of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
- Biomed. Pharmacother. 2020 Dec 1; 132: 110859.
AbstractCoronaviruses (CoVs) are a member of the Coronaviridae family with positive-sense single- stranded RNA. In recent years, the CoVs have become a global problem to public health. The immune responses (innate and adaptive immunity) are essential for elimination and clearance of CoVs infections, however, uncontrolled immune responses can result in aggravating acute lung injury and significant immunopathology. Gaining profound understanding about the interaction between CoVs and the innate and adaptive immune systems could be a critical step in the field of treatment. In this review, we present an update on the host innate and adaptive immune responses against SARS-CoV, MERS-CoV and newly appeared SARS-CoV-2.Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.
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