• Roger A Dashner, Allahyar Kangarlu, David L Clark, Abhik RayChaudhury, and Donald W Chakeres.
• Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio 43210-1228, USA.
• J Magn Reson Imaging. 2004 Mar 1; 19 (3): 303-7.

PurposeTo quantify the minimum magnetic resonance imaging (MRI) spatial resolution of the visible deoxygenated microscopic vessels of the human brain at 8 T.Materials And MethodsThis study compared 8-T gradient echo (GE) images of a human cadaver brain having an in-plane resolution of 195 x 195 microm to corresponding digital photographs of 205 cryomicrotome sections of the same cadaver brain, along with summed images of 25 contiguous cryomicrotome sections. One-millimeter-thick GE images of a 1-cm-thick unfixed whole coronal brain section were acquired using techniques similar to those commonly utilized for 8-T human imaging in vivo.ResultsThere was excellent MR visualization of the deoxygenated microscopic vessels within the brain down to a resolution of approximately 100 microm.ConclusionBy taking advantage of magnetic susceptibility-based blood oxygenation level-dependent (BOLD) contrast, deoxygenated microscopic blood vessels smaller than the pixel dimensions used for imaging can be visualized using a whole-body 8-T MRI system.Copyright 2004 Wiley-Liss, Inc.

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