• María Verónica Bravo, Daniel Bunout, Laura Leiva, María Pía de la Maza, Gladys Barrera, Javier de la Maza, and Sandra Hirsch.
• Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile. vbravol@vtr.net
• Rev Med Chil. 2008 Aug 1; 136 (8): 981-8.

BackgroundAntibiotic-associated diarrhea is one of the most common adverse effects of antimicrobials. Any antimicrobial can potentially produce diarrhea but beta-lactamics have a higher risk. Among these, amoxicillin is widely indicated in ambulatory practice. One of the alternatives suggested to prevent antibiotic-associated diarrhea, is the use of the probiotic Saccharomyces boulardii.AimTo evaluate whether the concomitant use of Saccharomyces boulardii and amoxicillin can prevent antibiotic associated diarrhea in ambulatory adults with acute infections diseases, without provoking other adverse effects.Material And MethodsEighty six adults (aged 15 to 81 years) with acute infectious diseases, excluding those arising in the gastrointestinal tract, that received a prescription of oral amoxicillin for 5 to 10 days, were included. In a controlled randomized, double blind trial, 41 patients were assigned to receive lyophilized Saccharomyces boulardii (500 mg/day) during 12 days, and 45 patients were assigned to placebo for the same period.ResultsTen percent of patients (9/86) reported acute diarrhea, 9,8% (4/41) in the experimental group and 11.196 (5/45) in the control group (p = 100). No adverse effects were associated to the use of the probiotic.ConclusionsSaccharomyces boulardii (500 mg/day) did not prevent diarrhea related to amoxicillin.

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