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Jpn. J. Infect. Dis. · Mar 2021
Observational StudyWhen Clinicians Should Repeat RT-PCR for SARS-CoV-2: Repeat PCR Testing in Patients with Pulmonary CT Findings Suggestive of COVID-19.
- Kei Yamamoto, Sho Saito, Kayoko Hayakawa, Masao Hashimoto, Jin Takasaki, and Norio Ohmagari.
- Disease Control and Prevention Center, National Center for Global Health and Medicine, Japan.
- Jpn. J. Infect. Dis. 2021 Mar 24; 74 (2): 161-165.
AbstractReal-time reverse transcription polymerase chain reaction (RT-PCR) tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are occasionally repeated when clinicians suspect false-negative results, but the conditions under which repeated RT-PCR testing is warranted remain unclear. We evaluated the practice of repeat RT-PCR testing for SARS-CoV-2 in 45 patients who were retested after an initial negative PCR test. Of these, the diagnosis of coronavirus disease (COVID-19) was confirmed in four patients with typical chest computed tomography (CT) findings and in one patient without typical CT findings in whom the test result was strongly suspected to be false-positive. We recommend repeat RT-PCR testing only for patients with typical CT findings of COVID-19.
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