• Jean-Christophe Ferré, Jan Petr, Christian Barillot, Hélène Raoult, and Jean-Yves Gauvrit.
• CHU Rennes, Department of Neuroradiology, Hôpital Pontchaillou, Rennes, France. ean-christophe.ferre@chu-rennes.fr
• J Comput Assist Tomogr. 2013 Mar 1; 37 (2): 247-51.

ObjectiveThe quantification of cerebral blood flow using pulsed arterial spin labeling could be erroneous with a nonoptimal inversion time (TI). We suggest that the optimal individual TI is dependent on the hemodynamic values of the supra-aortic vessels.MethodsTwenty-two healthy volunteers (mean age, 31.8 years) underwent 7 pulsed arterial spin labeling scans at 3 T with TI ranging from 1200 to 1800 milliseconds every 100 milliseconds. The quantitative hemodynamic values of carotids were computed using a cine phase-contrast sequence. Optimal TIs were determined using visual and quantitative criteria. A correlation was sought between each optimal individual TI criterion and the hemodynamic parameter values.ResultsThe optimal group TI was 1700 milliseconds. The individual analysis showed a significant correlation between the optimal TI of white matter signal-to-noise ratio and stroke distance, and the optimal TI of contrast-to-noise ratio with mean velocity.ConclusionsA correlation was found between optimal individual TIs and carotid hemodynamic parameters.

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